Spybot-S&D can be freezed up if the servers are reacting very slowly. This often happens the day new updates are released, when too many people try to download them at the same time - it is just delayed though and very slow in reacting. There are a few possible solutions for this problem:

1. Wait a minute, it should be active again.
2. Select a different download location: After Search for update, you can select another mirror in the toolbar. To do that, click the small arrow next to the currently selected mirror name.
3. Please try again later.

Information about updating is also available in our section How to (online link; includes a screenshot); take a look at point 5 of this description that shows you how to select a different download location.